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Transcription factor required for formation of positional identity in the developing retina, regionalization of the optic chiasm and morphogenesis of the kidney. Can neutralize ectodermal cells directly. Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis. Probable transcription factor involved in embryogenesis and somatogenesis. FOXD1 is involved in regulating inflammation as well as kidney and retinal development. FOXD1 regulates the activity of NFAT and NFkB. Deficiency of FOXD1 results in multiorgan systemic inflammation, exaggerated Th cell-derived cytokine production, and T cell proliferation in autogolgous MLRs. In kidneys, FOXD1 controls the production of signals required for the normal transition of induced mesenchyme into tubular epithelium and full growth and branching of the collecting system. Deletion of FOXD1 results in renal abnormalities. FOXD2 acts as a modulator of T cell activation.
AI385632; AI426778; AIS1; BF-2; Brain factor 2; CWH3; Fkh2; FKHL17; FKHL8; FKHL9; forkhead box D1; forkhead box D2; forkhead box D3; forkhead box D4; forkhead box protein D1; FORKHEAD BOX PROTEIN D1 (FORKHEAD-RELATED PROTEIN FKHL8) (FORKHEAD-RELATED TRANSCRIPTION FACTOR 4) (FREAC-4); forkhead box protein D2; Forkhead box protein D3; forkhead box protein D4; forkhead homolog 2; forkhead, drosophila, homolog-like 17; Forkhead, drosophila, homolog-like 8; forkhead, Drosophila, homolog-like 9; forkhead-like 17; forkhead-like 8; forkhead-related activator 4; forkhead-related activator 5; forkhead-related activator 9; forkhead-related protein FKHL17; Forkhead-related protein FKHL8; forkhead-related protein FKHL9; Forkhead-related transcription factor 4; forkhead-related transcription factor 5; Forkhead-related transcription factor 9; Foxd1; FOXD2; FOXD3; Foxd4; FOXD4A; Freac4; FREAC-4; FREAC5; FREAC-5; FREAC9; FREAC-9; Genesis; Hepatocyte nuclear factor 3 forkhead homolog 2; Hfh10; HFH2; HFH-2; Hfhbf2; HFH-BF-2; HNF3/FH transcription factor genesis; HNF-3/forkhead homolog 2; HNF-3/forkhead homolog, brain factor 2; Mesoderm/mesenchyme forkhead 2; Mf2; MF-2; myeloid factor-alpha; Transcription factor FKH-2; VAMAS2
100 µL
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